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KMID : 0928520110210010021
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Korean Journal of Lipidology
2011 Volume.21 No. 1 p.21 ~ p.31
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Association between C-Reactive Protein Levels and Carotid Artery Intima-Media Thickness in Patients with Stable Coronary Artery Disease
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Kwon Jong-Bum
Lee Jong-Ho
Park Kyun
Kim Hyoung-Doo
Chang Kyung-Yoon
Kim Keon-Yeop
Her Sung-Ho
Baek Ju-Yeol
Park Mahn-Won
Cho Jung-Sun
Seung Ki-Bae
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Abstract
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Background: Although C-reactive protein (CRP) has emerged as an important predictor of cardiovascular disease, there is no report on its association with carotid artery intima-media thickness (IMT) in patients with coronary artery disease (CAD).
Methods: We examined the association between high-sensitivity (hs)-CRP levels and left carotid IMT in 688 stable CAD patients divided into lower and higher IMT groups.
Results: Of the 688 patients, 354 (51.5%) were in the lower IMT group and 334 (48.5%) were in the higher IMT group. By multivariable regression analysis, compared with the lower group, the higher group was significantly older (62.9±9.6 years vs. 56.3±10.6, p<0.001; OR=1.068), and had a higher mean fasting blood glucose level (113.6 ±38.8 vs. 103.7±36.0 mg/dL, p=0.010; OR=1.008), a higher prevalence of elevated blood pressure (57.8% vs. 45.5%, p=0.044; OR=1.446), a higher mean hs-CRP level (0.28±0.32 mg/dL vs. 0.23±0.28, p=0.043; OR=1.412) and more severe CAD (2-vessel vs. 1-vessel disease; OR=1.711, 3-vessel vs. 1-vessel disease; OR=1.714).
Conclusions: High hs-CRP levels appear to be a strong predictor of risk for atherosclerotic progression among patients with stable CAD.
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KEYWORD
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C-reactive protein, Coronary artery disease, Intima-media thickness
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